Studies

COVID-19 UPDATE

We hope you and your loved ones are safe as we all manage the impacts of the COVID-19 pandemic. For the ongoing CARILLON Trial, protecting the safety of patients and researchers is paramount. In this spirit, Cardiac Dimensions has temporarily paused new trial enrollment, effective May 8, 2020. We are continually monitoring the global pandemic and will resume trial enrollment when it is safe to do so.

Please send any inquiries to CARILLON@cardiacdimensions.com

The CARILLON Trial

If you have heart failure, you know how this condition affects your quality of life. Simple daily activities like preparing meals, visiting with friends, or even moving from room to room can require major effort and leave you exhausted. An estimated 26 million people suffer from heart failure worldwide, and the number is growing rapidly.

Nearly 75% of heart failure sufferers also have a leaky mitral valve, a condition known as mitral regurgitation (MR). Unfortunately, this further compromises the function of the heart – causing your heart failure to worsen over time.

If you struggle with heart failure symptoms or have been told you have a leaky valve, you may qualify for a new clinical study. The study is for the Carillon Mitral Contour System, an investigational implant designed to reshape the mitral valve and reduce leakage through a non-surgical approach.

Trial sites are currently located in the U.S., U.K., Poland, Greece and France. Interested patients may find out more about the trial at Clinical Trials (click here).

You can also contact Cardiac Dimensions at clinical@cardiacdimensions.com.

 

 

 

 

 

 

Previous Carillon System Studies

A Randomized Sham-Controlled Study of Percutaneous Mitral Annuloplasty in Functional Mitral Regurgitation: The REDUCE FMR Trial
Witte K, Lipiecki J, Siminiak T, et al.
J Am Coll Cardiol HF. DOI: 10.1016/j.jchf.2019.06.011

Coronary sinus-based percutaneous annuloplasty as treatment for functional mitral regurgitation: the TITAN II trial
Lipiecki J, Siminiak T, Sievert H, et al
BMJ Open Heart. 2016; 3: e000411

Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN Trial
Siminiak, T, Wu JC, Haude M, Hoppe UC, Sadowski J, Lipiecki J, Fajadet J, Shah AM, Feldman T, Kaye DM, Goldberg SL, Levy WC, Solomon SD, Reuter DG
Eur J Heart Fail. 2012 Aug; 14(8): 931-8

Percutaneous Mitral Annuloplasty for Functional Mitral Regurgitation Results of the CARILLON Mitral Annuloplasty Device European Union Study
Schofer J, Siminiak T Haude M, Herrman JP, Vainer J, Wu JC, Levy WC, Mauri L, Feldman T, Kwong RY, Kaye D, Duffy SJ, Tübler T, Degen H, Brandt MC, Van Bibber R, Goldberg S, Reuter DG, Hoppe UC
Circulation 2009; 120: 326-333