American Heart Journal
Kalmucki et al.
A comparison of clinical and echocardiographic outcomes of patients with HFrEF and proportionate and disproportionate FMR treated with indirect annuloplasty using the Carillon device. Pooled analysis of patients from 3 prospective studies that enrolled heart failure patients with persistent grade 2+ to 4+ FMR with >5.5 cm left ventricular (LV) end-diastolic diameter (LVEDD) and reduced ejection fraction.
- At 12 months, both groups showed improvements in all MR variables including regurgitant volume, EROA, and vena contracta.
- In patients with proportionate MR there were clinically relevant and statistically significant improvements in LV volumes and diameters.
- There was no independent relationship between the degree of proportionality as a continuous variable and the remodeling response to the Carillon therapy (change in LVEDV r=0.17; change in LVESV r=0.14).
- Percutaneous mitral annuloplasty with the Carillon device reduces MR in patients with both proportionate and disproportionate FMR, and also results in LV reverse remodeling in those with proportionate FMR.