VERÖFFENTLICHUNGEN
Journal of Clinical Medicine
Piotr Kałmucki et al
August 2026
In FMR patients undergoing the Carillon procedure, higher baseline LV volumes may predict more pronounced reverse remodeling, defined as a decrease in LV volumes. Higher values of vena contracta may predict larger reductions in the mitral annular area. High baseline LV diameters could suggest improvements in LV volumes in disproportionate FMR and in LV diameters in proportionate FMR, probably due to different LV geometries.
Global Cardiology
Janusz Lipiecki, Piotr Kalmucki, Larry E. Miller, Nicolas Durel
July 2026
A single-center extension of the REDUCE FMR trial provides the longest known follow-up for any transcatheter mitral repair therapy.
- Ten-year cardiovascular survival was 66% demonstrating long-term durability and treatment impact in an advanced heart failure population
- Median survival was 5.6 years in an elderly and high-risk FMR population
- Predictors of long-term outcomes included baseline LVEF less than 35% and early heart failure hospitalization
ESC Heart Failure
Holder Priebe-Brämer et al
November 2025
This was a single-centre retrospective study of 204 consecutive patients (age 83 ± 6 years, 68% female, 72% HFrEF) with NYHA class II-IV HF and moderate and moderate-to-severe (grade 2 + or 3+) SMR planned for CMCS implantation between 2021 and 2024.
At 3 months:
- NYHA class improved by ≥1 category in 94% of patients and 98% achieved NYHA class I or II.
- MR decreased by ≥1 grade in 91% of patients, with all patients classified as grade 1+ or 2+ post-procedure.
- Vena contracta width decreased (6.43 ± 0.84 to 3.85 ± 1.19 mm; P < 0.001), and there was a reduction of LA area from 44.4 ± 6.0 to 35.4 ± 5.1 cm2 (P < 0.001).
- Diastolic filling was improved (change in E/E′ ratio from 20.1 ± 5.5 to 14.0 ± 3.8; P < 0.001), systolic pulmonary artery pressure was lower in follow-up (44 ± 11 to 35 ± 9 mm; P < 0.001), and there was also a clinically relevant reduction in median BNP levels from 2849 to 1390 pg/mL (P < 0.001).
- These changes were not different between HFrEF and HFpEF.
